John Stamos, Gina Gershon and Kelsea Ballerini Are Among the Buzzy Stars BoardingDoctor Odysseyin New Trailer

Mar. 15, 2025

Expect a slew of familiar faces to pop up as guest stars onDoctor Odyssey.

Ryan Murphy’s brand-new medical procedural, premiering Thursday, Sept. 26, starsJoshua Jacksonas Max, a doctor aboard a luxury cruise ship called the Odyssey who navigates “unique medical crises” with the aide of his medical team “miles from shore," according to the synopsis.Doctor Odyssey’scast includesPhillipa Soo, Sean Teale andDon Johnson;John Stamos,Gina Gershon,Kelsea Ballerini,Cheyenne JacksonandChord Overstreetalso appear as guest stars throughout the first season.

The new trailer opens with Jackson’s character examining a female patient while Johnson’s character proudly explains to Soo and Teale that he selected Jackson from a competitive pool of 110 applicants.

In another scene, Johnson welcomes Jackson aboard the Odyssey, introducing him to Soo and Teale.

Joshua Jackson in ‘Doctor Odyssey.'.Disney

Disney

“You must be my brilliant nurses,” Jackson says.

“We are theship’sbrilliant and capable nurses. Yes.” Soo corrects him, eliciting an apology and a handshake from Jackson.

A sequence of scenes showcase passengers like Stamos, Jackson and Overstreet while Johnson declares via voiceover that the crew’s “mission” is to “preserve the dream.”

“And that’s why you’re here,” he adds.

Sean Teale, Don Johnson, Joshua Jackson and Phillipa Soo in ‘Doctor Odyssey.'.Pari Dukovic/Disney

Pari Dukovic/Disney

Afterwards, the two awkwardly ride the elevator in silence before they ask each other whether they want to talk about “what happened.”

“No, no, no. I’m good,” Jackson says as Soo quickly replies, “Then great. Great.”

As the trailer offers more glimpses of the opulent experiences the Odyssey offers — including a grand ballroom with a disco ball, and a freewheeling beachside party — Johnson explains that while they’ve “constructed a paradise,” they have to be “prepared for everything.”

“It’s your job to keep everyone alive,” Johnson tells Jackson.

Phillipa Soo and Joshua Jackson in ‘Doctor Odyssey.'.Tina Thorpe/Disney

Tina Thorpe/Disney

“I’m in,” Jackson responds.

“In life, it’s not a question of when you encounter waves, but when you do when they come up,” Johnson adds through voiceover.

The next scenes hint at several other challenges the Odyssey crew encounters, including a possible collision that has one crewmember hanging on as the ship tilts to the side.

“We’re becoming some kind of team, aren’t we?” Jackson asks Soo and Teale rhetorically, before the trailer cuts to the show’s title.

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Doctor Odysseypremieres Thursday, Sept. 26 at 9 p.m. ET on ABC.

source: people.com